The superpro uses Cycle Timing Analysis on the depth filters and AEX columns. They discover that a single column is idle 65% of the time waiting for the bioreactor harvest.
The superpro simplifies the model using "Pseudo-Continuous" blocks. They replace the dynamic bioreactor with a series of CSTRs (Continuous Stirred-Tank Reactors) and use the Rate-Based kinetics tab. superpro designer examples
They model a "staggered harvest" strategy—overlapping batches so the column is always loaded. The simulation predicts a 40% boost in annual grams. Management approves the SOP change based purely on the simulation report. 3. Retrofit vs. Greenfield: The Active Pharmaceutical Ingredient (API) Decision The Challenge: A chemical plant needs to scale a new small-molecule API from 100 kg to 10 metric tons per year. Should they retrofit an old reactor or build new? The superpro uses Cycle Timing Analysis on the
If you’ve spent any time in process engineering, you know that SuperPro Designer is the gold standard for batch and continuous process simulation. But knowing the software and mastering it are two different things. They replace the dynamic bioreactor with a series
The simulation reveals that the continuous capture step (three columns in series) fails if the upstream perfusion rate dips by just 8%. They add a surge tank that the average user would have forgotten. The model saves $2M in failed pilot runs. 5. The Environmental "What If" (Water & Solvent Recycle) The Challenge: A plant is hitting its effluent limit for organic solvents. Purchasing a distillation column is expensive.
An expert user sets up "Campaign Mode" with staggered scheduling. Instead of modeling one batch, they chain 50 batches of Product A, followed by a cleaning cycle, then 30 of Product B.
Here are five real-world examples of how power users leverage SuperPro Designer to solve problems that stump average engineers. The Challenge: A CDMO needs to simulate a facility producing three different mAbs in the same stainless steel bioreactor train. Cleaning, hold times, and changeover kill throughput.